Unit 14 Protein Structure and Function
EI: Proteins have a very wide range of functions in living organisms.
IB Assessment Statements
Drawing molecular diagrams of glucose, ribose, a saturated fatty acid and a generalized amino acid.
There are 20 different amino acids in polypeptides synthesized on ribosomes.
Some fatty acids and some amino acids are essential.
Essential nutrients cannot be synthesized by the body, therefore they have to be included in the diet.
Lack of essential amino acids affects the production of proteins.
Looking for patterns, trends, and discrepancies- most but not all organisms assemble proteins from the same amino acids.
Protein Folding (Structure)
Amino acids are linked together by condensation to form polypeptides.
Drawing molecular diagrams to show the formation of a peptide bond.
Amino Acids can be linked together in any sequence giving a huge range of possible polypeptides.
The amino acid sequence of polypeptides is coded for by genes.
The sequence and number of amino acids in the polypeptide is the primary structure.
The secondary structure is the formation of alpha helices and beta pleated sheets stabilized by hydrogen bonding.
The tertiary structure is the further folding of the polypeptide stabilized by interactions between R groups.
A protein may consist of a single polypeptide or more than one polypeptide linked together.
The amino acid sequence determines the three-dimensional conformation of a protein.
The quaternary structure exists in proteins with more than one polypeptide chain (may also involve the binding of a prosthetic group to form a conjugated protein).
2.4.U8: Every individual has a unique proteome.
Living organisms synthesize many different proteins with a wide range of functions.
Rubisco, insulin, immunoglobulins, rhodopsin, collagen and spider silk as examples of the range of protein functions.
Amino Acids Notes
Amino Acid and Peptide Bond Animation
How to tell if an amino acid is polar or non polar Video
An Evolutionary Perspective on Amino Acids Article
Life Cycle of a Protein Animation
"Proteins Rule" Article
Protein Folding Notes
JMOL Activity (JAVA Required)
Protein Folding Video
Protein Function Notes
Proteome Reading #1
Proteome Reading #2
Proteome Reading #3
Acideroids Game (Amino Acids)